Alan Murphy

Computational Biologist, PhD Student, Imperial College London

   

Hey, I'm Alan, a computational biologist undertaking my PhD in Dr. Nathan Skene's group in the UK Dementia Research Institute (UK DRI) at the Department of Brain Sciences, Imperial College London. I use machine learning to help us understand how genetics, epigenetics and transcriptomics interact in disease settings and to understand fundamental cellular mechanisms, such as gene regulation. I'm committed to promoting reproducbility and transparency through the development of open-access bioinformatic tools. Outside of research, I'm equally obsessive over food, craft beer and coffee. If you ever need to kill an hour, mention one of these to me.

 

News

16th Nov, 2024             Our Enformer Celltyping paper a genomic DNN to accurately predict epigenetic                                       signals in previously unseen cell types is out in Nature Comms!                                       See more on Twitter or on BlueSky.

4th Dec, 2023               Our re-analysis paper of the first single-cell RNA-Seq Alzheimer's disease                                       is out in eLife! Check out an overview here.

25th Sep, 2023             Presented my PhD work predicting the cell type-specific effects of genetic                                       variants on the epigenome at the Kipoi Summit for computational regulatory                                       computational genomics.

29th Jul, 2023               Presented a session on single-cell genomics for Alzheimer's disease as part of                                       ADDI's Summer Learning Series.

22nd Dec, 2022            Our paper benchmarking differential expression methods for single-cell                                       RNA-Seq is out in Nature Communications! Check out our overview here.

2nd Oct, 2021               MungeSumstats our software for the rapid standardisation and quality control of                                       GWAS or QTL summary statistics is now out in Bioinformatics!

19th Jul, 2021               Thrilled to offically start my PhD with Dr. Nathan Skene's group in the Department                                       of Brain Sciences, Imperial College London as part of the UK DRI!

Selected Publications