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Published in Bioinformatics, 2021
we have developed MungeSumstats, a Bioconductor R package for the standardization and quality control of GWAS summary statistics. MungeSumstats can handle the most common summary statistic formats, including variant call format (VCF) producing a reformatted, standardized, tabular summary statistic file, VCF or R native data object.
Recommended citation: Murphy, A. E., Schilder, B. M. & Skene, N. G. Bioinformatics 37, 4593–4596 (2021) https://academic.oup.com/bioinformatics/article/37/23/4593/6380562
Published in Nature Communications, 2022
Based on our findings, we recommend the use of pseudobulk approaches for differential expression in single-cell RNA-sequencing analyses.
Recommended citation: Murphy, A. E. & Skene, N. G. Nat. Commun. 37, 7851 (2022) https://www.nature.com/articles/s41467-022-35519-4
Published in eLife, 2023
Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimers disease single nucleus RNA-seq dataset.
Recommended citation: Murphy, A. E., Fancy, N. & Skene, N. G. eLife 12:RP90214 (2023) https://elifesciences.org/articles/90214
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Masters course, Faculty of Medicine, 2023
A data science course covering dimensionality reduction, unsupervised and supervised machine learning techniques applied to biological datasets.
Undergraduate course, Faculty of Medicine, 2023
A statistics workshop covering the principles of statistical analyses of biological data and experimental design.